Table 1: Calculated α for PCI of FG-BLM and FG-DOX.
Time (hours) | ||||
Treatment groups | 2 | 24 | 48 | 72 |
FG-BLM | 1.8* | 3.8 | 5.6 | 4.6 |
FG-DOX | 2.3 | 3.4 | 4.3 | 2.2 |
*α value. α is defined as the ratio of the cumulative effect of 2 therapies, PDT and drug, administered independently to the net effect of combining the 2 therapies at a given dose. If α > 1, the result is synergistic (supra-additive). If α < 1, the result is antagonistic, and if α = 1 the result is simply additive.