Mean (SD) at VOC

Mean (SD) at steady state

Mean difference (SE)

p-value, two-sided paired t-test

Serum UA

5.24 (1.71)

5.22 (1.43)

 0.0125 (0.319)

0.9699

Urine UA: Cr ratio

0.48 (0.26)

0.62 (0.20)

-0.1367 (0.156)

0.4097

Simkin Index

0.24 (0.13)

0.30 (0.14)

-0.05 (0.089)

0.4748

mSchwartz Cr-eGFR

129.6 (30.4)

142.2 (27.0)

-12.69 (6.16)

0.0785

PedsQL Score

47.8 (20.9)

56.0 (10.8)

8.20 (4.76)

0.1283

Hemoglobin

8.59 (1.7)

9.15 (0.8)

-0.56 (0.64)

0.4065

Biomarkers

Urine IL-18, pg/mL

93.41 (59.09)

49.26 (21.54)

44.153 (17.61)

0.0406*

Urine KIM-1, pg/mL

588.51 (699.56)

472.68 (385.32)

115.83 (164.03)

0.5029

Urine Endothelin-1, pg/mL

0.39 (0.42)

0.26 (0.23)

0.13 (0.18)

0.5024

Urine NAG, U/L

5.68 (4.13)

4.63 (0.82)

1.05 (1.45)

0.4916

Urine Nlrp3, ng/mL

1.45 (3.01)

0.55 (0.53)

0.90 (0.89)

0.3465

Serum CRP, mg/dL

4.49 (10.26)

0.4 (0.24)

4.09 (3.83)

0.3267