Table 1: Summary of proteins responsible for amyloidosis, the corresponding abbreviations and the key characteristics associated with each.
Amyloidogenic protein | Abbreviation | Characteristics |
Immunoglobulin light chain | AL | Primary amyloidosis, plasma cell dyscrasias. Cardiomyopathy, hepatomegaly, nephrotic syndrome. |
Immunoglobulin heavy chain | AH | Plasma cell dyscrasias, renal involvement. |
Transthyretin | ATTR | Familial amyloidosis, systemic, associated with peripheral neuropathy and cardiomyopathy. |
Leukocyte chemotactic factor 2 | ALECT 2 | Renal dysfunction, lack of cardiac or nerve involvement. |
Serum amyloid A | AA | Acquired, reactive, systemic, linked to inflammatory disorders or chronic infection. Proteinuria, loss of renal function. |
Apolipoprotein A-I | AApoAI | Autosomal dominant systemic, organ involvement related to specific mutations. |
Apolipoprotein A-II | AApoAII | Autosomal dominant systemic, renal failure. |
Lysozyme | ALys | Autosomal dominant, GI and renal dysfunction. |
Fibrinogen | AFib | Autosomal dominant, deposition in kidney, heart, liver, and spleen; prominent renal involvement. |
Gelsolin | AGel | Autosomal dominant, polyneuropathy, corneal lattice dystrophy. |
β2-microglobulin | Aβ2M | Hemodialysis-related amyloidosis with musculoskeletal manifestations. |