Table 3: Univariate and multivariate analyses.

Covariates

Univariate

Multivariate model 1

Multivariate model 2

 

P

HR

95%CI

P

HR

95%CI

P

HR

95%CI

Log Age

0.003

3.76

1.55-9.10

0.001

4.90*

1.93-12.46

0.04

3.34*

1.07-10.4

Sex Male

0.001

1.91

1.31-2.78

< 0.001

2.13*

1.45-3.12

0.05

1.54*

1.00-2.38

Obesity

0.01

1.61

1.10-2.34

0.006

1.69*

1.16-2.46

0.002

1.88*

1.25-2.83

Charlson index

0.003

1.08

1.03-1.14

0.44

 

 

/

 

 

Number of comorbidities

0.002

1.12

1.04-1.21

0.23

 

 

/

 

 

Any comorbidity

0.02

1.81

1.12-2.93

0.47

 

 

/

 

 

Connective disease

0.05

2.15

1.01-4.60

0.57

 

 

/

 

 

Hypertension

0.03

1.43

1.03-1.98

0.85

 

 

/

 

 

Log SOFA score

< 0.001

1.72

1.28-2.31

0.009

1.52

1.11-2.08

< 0.001

1.89*

1.33-2.69

Log initial SpO2/FiO2 ratio

< 0.001

0.32

0.26-0.39

< 0.001

0.36

0.29-0.44

< 0.001

0.35*

0.28-0.43

Log N/L ratio

< 0.001

1.99

1.63-2.45

< 0.001

1.85

1.51-2.28

0.006

1.36

1.09-1.69

Log D-dimer

< 0.001

1.43

1.25-1.63

< 0.001

1.42

1.23-1.64

0.74

 

 

Log PCT

< 0.001

1.51

1.37-1.66

< 0.001

1.46

1.32-1.62

0.004

1.23

1.07-1.41

Log CRP

< 0.001

1.78

1.48-2.16

< 0.001

1.67

1.37-2.02

0.02

1.28

1.04-1.59

Log Ferritin

0.001

1.56

1.20-2.01

0.005

1.52

1.14-2.03

0.26

 

 

Log HS troponin I

< 0.001

1.25

1.14-1.36

< 0.001

1.25

1.13-1.39

0.03

1.13

1.01-1.27

Log Proteinuria

< 0.001

1.77

1.32-2.37

< 0.001

1.75

1.29-2.37

0.004

1.62

1.17-2.24

Log Creatinine

0.03

1.35

1.02-1.77

0.44

 

 

/

 

 

Log LDH

< 0.001

3.85

2.77-5.34

< 0.001

3.56

2.52-5.01

< 0.001

2.31

1.54-3.46

Log Albumin

0.02

0.31

0.12-0.82

0.06

0.38

0.14-1.05

0.44

 

 

Not-normal distributed variables were transformed into a logarithmic scale.

Multivariate Model 1: Cox proportional-hazard model adjusted for: age, sex and obesity.

Multivariate Model 2: Cox proportional-hazard model adjusted for: age, sex, obesity, SpO2/FiO2 ratio and SOFA score.

Abbreviations: N/L: Neutrophils/leucocytes ratio; PCT: Procalcitonin; CRP: C-reactive protein; LDH: Lactate dehydrogenase; SpO2/FiO2: Oxygen saturation to fraction of inspired oxygen ratio; SOFA: Sequential organ failure assessment.