Table 4: Relative
sensitivity indices (RSI) of P.
falciparum cyclically exposed to Artemisia
annua blend at IC90 and tested against (i) artemisinin, (ii) A. annua blend and (iii) chloroquine.
Cycles |
ART Mean ± SE |
Blend Mean ± SE |
CQ Mean ± SE |
RSI
cycle 10 |
1.28
± 0.06a |
1.06
± 0.04b |
1.01
± 0.02b |
RSI
cycle 20 |
14.40
± 0.63b |
0.11
± 0.01a |
1.09
± 0.04b |
RSI
cycle 30 |
19.25
± 3.25b |
0.67
± 0.10b |
0.10
± 0.02a |
RSI
cycle 40 |
36.38
± 0.40c |
5.37
± 0.33c |
0.15
± 0.01a |
P-value |
<
0.001 |
<
0.001 |
<
0.001 |
Mean ± SE followed by the same letter(s) within the same
column do not differ significantly from one another (One-way ANOVA, SNK-test, α
= 0.05).