Table 4: Relative sensitivity indices (RSI) of P. falciparum cyclically exposed to Artemisia annua blend at IC90 and tested against (i) artemisinin, (ii) A. annua blend and (iii) chloroquine.

Cycles

ART Mean ± SE

Blend Mean ± SE

CQ Mean ± SE

RSI cycle 10

1.28 ± 0.06a

1.06 ± 0.04b

1.01 ± 0.02b

RSI cycle 20

14.40 ± 0.63b

0.11 ± 0.01a

1.09 ± 0.04b

RSI cycle 30

19.25 ± 3.25b

0.67 ± 0.10b

0.10 ± 0.02a

RSI cycle 40

36.38 ± 0.40c

5.37 ± 0.33c

0.15 ± 0.01a

P-value

< 0.001

< 0.001

< 0.001

 

Mean ± SE followed by the same letter(s) within the same column do not differ significantly from one another (One-way ANOVA, SNK-test, α = 0.05).