Table 3: Relative
sensitivity indices (RSI) of P.
falciparum cyclically exposed to A. annua blend at IC50 and tested against (i) artemisinin, (ii) A.
annua blend,- and (iii) chloroquine.
Cycles |
ART Mean ± SE |
Blend Mean ± SE |
CQ Mean ± SE |
RSI
cycle 10 |
0.93
± 0.06a |
0.83
± 0.02b |
0.95
± 0.02c |
RSI
cycle 20 |
3.00
± 0.08b |
0.17
± 0.01a |
1.10
± 0.03d |
RSI
cycle 30 |
27.99
± 0.48c |
0.85
± 0.05b |
0.23
± 0.00a |
RSI
cycle 40 |
29.00
± 1.15c |
2.14
± 0.08c |
0.29
± 0.01b |
p-value |
<
0.001 |
<
0.001 |
<
0.001 |
Mean ± SE followed by the same letter(s) within the same
column do not differ significantly from one another (One-way ANOVA, SNK-test, α
= 0.05).