Table 3: Relative sensitivity indices (RSI) of P. falciparum cyclically exposed to A. annua blend at IC50 and tested against (i) artemisinin, (ii) A. annua blend,- and (iii) chloroquine.

Cycles

ART Mean ± SE

Blend Mean ± SE

CQ Mean ± SE

RSI cycle 10

0.93 ± 0.06a

0.83 ± 0.02b

0.95 ± 0.02c

RSI cycle 20

3.00 ± 0.08b

0.17 ± 0.01a

1.10 ± 0.03d

RSI cycle 30

27.99 ± 0.48c

0.85 ± 0.05b

0.23 ± 0.00a

RSI cycle 40

29.00 ± 1.15c

2.14 ± 0.08c

0.29 ± 0.01b

p-value

< 0.001

< 0.001

< 0.001

 

Mean ± SE followed by the same letter(s) within the same column do not differ significantly from one another (One-way ANOVA, SNK-test, α = 0.05).