Table 2: Relative sensitivity indices (RSI) of P. falciparum cyclically exposed to artemisinin at IC90 and tested with (i) artemisinin, (ii) A. annua blend, and (iii) chloroquine.

Cycles

ART Mean ± SE

Blend Mean ± SE

CQ Mean ± SE

RSI cycle 10

0.82 ± 0.13a

0.61 ± 0.12b

1.11 ± 0.01a

RSI cycle 20

7.36 ± 0.13b

1.51 ± 0.08c

1.53 ± 0.08b

RSI cycle 30

16.04 ± 1.24c

0.22 ± 0.01a

1.13 ± 0.05a

p-value

< 0.001

< 0.001

0.002

 

Mean ± SE followed by the same letter(s) within the same column do not differ significantly from one another (One-way ANOVA, SNK-test, α = 0.05).