Table 1: Relative sensitivity indices (RSI) of P. falciparum cyclically exposed to artemisinin at IC50 and tested with (i) artemisinin, (ii) A. annua blend and (iii) chloroquine.

Cycles

ART Mean ± SE

Blend Mean ± SE

CQ Mean ± SE

RSI cycle 10

1.81 ± 0.83a

0.09 ± 0.01a

1.01 ± 0.03a

RSI cycle 20

2.42 ± 0.84a

0.09 ± 0.01a

1.13 ± 0.10b

RSI cycle 30

22.66 ± 2.95b

1.89 ± 0.14b

0.87 ± 0.01a

RSI cycle 40

26.45 ± 0.87b

0.07 ± 0.00a

1.43 ± 0.03c

p-value

< 0.001

< 0.001

< 0.001

 

Mean ± SE followed by the same letter(s) within the same column do not differ significantly from one another (One-way ANOVA, SNK-test, α = 0.05).