Table
1: Relative
sensitivity indices (RSI) of P.
falciparum cyclically exposed to artemisinin at IC50 and tested
with (i) artemisinin, (ii) A. annua blend and (iii) chloroquine.
Cycles |
ART Mean ± SE |
Blend Mean ± SE |
CQ Mean ± SE |
RSI
cycle 10 |
1.81
± 0.83a |
0.09
± 0.01a |
1.01
± 0.03a |
RSI
cycle 20 |
2.42
± 0.84a |
0.09
± 0.01a |
1.13
± 0.10b |
RSI
cycle 30 |
22.66
± 2.95b |
1.89
± 0.14b |
0.87
± 0.01a |
RSI
cycle 40 |
26.45
± 0.87b |
0.07
± 0.00a |
1.43
± 0.03c |
p-value |
<
0.001 |
<
0.001 |
<
0.001 |
Mean ± SE followed by the same letter(s) within the same
column do not differ significantly from one another (One-way ANOVA, SNK-test, α
= 0.05).