Table 2: The correlations among bone metabolism biomarkers.
Bone metabolism biomarkers | Correlated parameters | ||||
Ca | Month 0 | A | TCh | iPTH | |
(mmol/L) | P, t, β | 0.020a, 2.345, 0.156 | 0.012a, 2.536, 0.170 | 0.001b, - 3.409, - 0.229 | |
Month 24 | SCr | TCh | |||
P, t, β | < 0.001a, 3.909, 0.315 | < 0.001a, - 4.098, 0.328 | |||
P | Month 0 | Hb | SCr | eGFR | OPN |
(mmol/L) | P, t, β | 0.003b, 2.345, 0.156 | < 0.001b, 3.962, 0.347 | 0.042a, - 2.048, - 0.188 | 0.018a, 2.385, 0.134 |
Month 24 | Hb | SCr | |||
P, t, β | 0.007b, - 2.710, - 0.168 | < 0.001b, 6.009, 0.492 | |||
ALP | Month 0 | CRP | |||
(U/L) | P, t, β | < 0.001b, 5.007, 0.332 | |||
Month 24 | CRP | Ca | |||
P, t, β | < 0.001b, 5.599, 0.365 | 0.016a, - 2.419, -0.155 | |||
iPTH | Month 0 | Ca | SCr | ||
(pg/ml) | P, t, β | < 0.001b, - 4.552, - 0.281 | 0.002b, 3.140, 0.311 | ||
Month 24 | Ca | SCr | eGFR | ||
P, t, β | < 0.001b, - 4.794, - 0.271 | < 0.001b, 4.339, 0.416 | 0.024a, - 2.277, -0.219 | ||
25(OH) D | Month 0 | None | |||
(ng/ml) | P, t, β | ||||
Month 24 | FGF-23 | BMP-7 | |||
P, t, β | 0.024a, - 2.272, - 0.135 | < 0.001b, 8.644, 0.514 | |||
FGF-23 | Month 0 | None | |||
(pg/ml) | P, t, β | ||||
Month 24 | 25(OH) D | ||||
P, t, β | 0.011a, - 2.572, - 0.177 | ||||
Klotho | Month 0 | BMP-7 | |||
(ng/ml) | P, t, β | < 0.001b, 3.756, 0.254 | |||
Month 24 | Ca | ||||
P, t, β | 0.034a, - 2.130, - 0.148 | ||||
OPN | Month 0 | P | BMP-7 | ||
(pg/ml) | P, t, β | 0.006b, 2.792, 0.184 | < 0.001b, - 4.590, - 0.302 | ||
Month 24 | None | ||||
P, t, β | |||||
BMP-7 | Month 0 | Hb | Klotho | OPN | |
(ng/ml) | P, t, β | 0.023a, 2.285, 0.147 | < 0.001b, 3.897, 0.250 | < 0.001b, - 4.575, - 0.295 | |
Month 24 | 25(OH) D | ||||
P, t, β | < 0.001b, 8.827, 0.528 |
The significant correlated parameters of each bone metabolism biomarkers in month 0 and 24 were listed.
Abbreviations: Hb: Hemoglobin; hsCRP: High Sensitive C Reactive Protein; A: Albumin; SCr: Serum Creatinine; eGFR: Estimated Glomerular Filtration Ratio; TCh: Total Cholesterol; TG: Triglycerides; Ca: Calcium; P: Phosphorus; ALP: Alkaline Phosphatase; iPTH: Intact Parathyroid Hormone; 25(OH)D: 25-hydroxyvitamin D; FGF: Fibroblast Growth Factor; BMP: Bone Morphogenetic Protein; OPN: Osteopontin; β: Standardized Coefficient. a P < 0.05, b P < 0.01.