Table 2: The correlations among bone metabolism biomarkers.

Bone metabolism biomarkers Correlated parameters
Ca Month 0 A TCh iPTH
(mmol/L) P, t, β 0.020a, 2.345, 0.156 0.012a, 2.536, 0.170 0.001b, - 3.409, - 0.229
Month 24 SCr TCh
P, t, β < 0.001a, 3.909, 0.315 < 0.001a, - 4.098, 0.328
P Month 0 Hb SCr eGFR OPN
(mmol/L) P, t, β 0.003b, 2.345, 0.156 < 0.001b, 3.962, 0.347 0.042a, - 2.048, - 0.188 0.018a, 2.385, 0.134
Month 24 Hb SCr
P, t, β 0.007b, - 2.710, - 0.168 < 0.001b, 6.009, 0.492
ALP Month 0 CRP
(U/L) P, t, β < 0.001b, 5.007, 0.332
Month 24 CRP Ca
P, t, β < 0.001b, 5.599, 0.365 0.016a, - 2.419, -0.155
iPTH Month 0 Ca SCr
(pg/ml) P, t, β < 0.001b, - 4.552, - 0.281 0.002b, 3.140, 0.311
Month 24 Ca SCr eGFR
P, t, β < 0.001b, - 4.794, - 0.271 < 0.001b, 4.339, 0.416 0.024a, - 2.277, -0.219
25(OH) D Month 0 None
(ng/ml) P, t, β
Month 24 FGF-23 BMP-7
P, t, β 0.024a, - 2.272, - 0.135 < 0.001b, 8.644, 0.514
FGF-23 Month 0 None
(pg/ml) P, t, β
Month 24 25(OH) D
P, t, β 0.011a, - 2.572, - 0.177
Klotho Month 0 BMP-7
(ng/ml) P, t, β < 0.001b, 3.756, 0.254
Month 24 Ca
P, t, β 0.034a, - 2.130, - 0.148
OPN Month 0 P BMP-7
(pg/ml) P, t, β 0.006b, 2.792, 0.184 < 0.001b, - 4.590, - 0.302
Month 24 None
P, t, β
BMP-7 Month 0 Hb Klotho OPN
(ng/ml) P, t, β 0.023a, 2.285, 0.147 < 0.001b, 3.897, 0.250 < 0.001b, - 4.575, - 0.295
Month 24 25(OH) D
P, t, β < 0.001b, 8.827, 0.528

The significant correlated parameters of each bone metabolism biomarkers in month 0 and 24 were listed.

Abbreviations: Hb: Hemoglobin; hsCRP: High Sensitive C Reactive Protein; A: Albumin; SCr: Serum Creatinine; eGFR: Estimated Glomerular Filtration Ratio; TCh: Total Cholesterol; TG: Triglycerides; Ca: Calcium; P: Phosphorus; ALP: Alkaline Phosphatase; iPTH: Intact Parathyroid Hormone; 25(OH)D: 25-hydroxyvitamin D; FGF: Fibroblast Growth Factor; BMP: Bone Morphogenetic Protein; OPN: Osteopontin; β: Standardized Coefficient. a P < 0.05, b P < 0.01.