Table 1: Hepatotoxicity and MTX plasma concentrations after high-dose MTX administration.
|
Date |
MTX Dose (mg/m2) |
ALT (U/L)
|
GGT (U/L)
|
MTX PC (µmol/L) |
|
ALL treatment at debut SEHOP-PETHEMA/13 |
|
|
|
|
|
20-12-2017 |
5 |
|
|
|
|
21-12-2017 |
|
47 |
21 |
|
|
22-12-2017 |
|
467 |
18 |
0.54 |
|
28-12-2017 |
|
641 |
|
|
|
02-01-2018 |
|
166 |
30 |
|
|
08-01-2018 |
5 |
|
|
|
|
10-01-2018 |
|
113 |
70 |
0.68 |
|
11-01-2018 |
|
126 |
69 |
|
|
17-01-2018 |
|
46 |
58 |
|
|
21-01-2018 |
|
27 |
40 |
|
|
25-01-2018 |
5 |
|
|
|
|
27-01-2018 |
|
338 |
45 |
0.56 |
|
28-01-2018 |
|
318 |
42 |
|
|
07-02-2018 |
|
51 |
29 |
|
|
08-02-2018 |
5 |
|
|
|
|
10-02-2018 |
|
40 |
|
0.64 |
|
20-02-2018 |
|
32 |
19 |
|
|
26-02-2018 |
|
24 |
15 |
|
|
ALL treatment at relapse SEHOP-PETHEMA/15 |
|
|
|
|
|
16-07-2020 |
1 |
|
|
|
|
18-07-2020 |
|
191 |
23 |
1.11 |
|
19-07-2020 |
|
279 |
27 |
|
|
20-07-2020 |
|
483 |
30 |
|
|
21-07-2020 |
|
456 |
36 |
|
|
20-10-2020 |
1 |
|
|
|
|
22-10-2020 |
|
121 |
45 |
7.04 |
|
25-10-2020 |
|
87 |
40 |
|
|
27-10-2020 |
|
74 |
40 |
|
|
12-11-2020 |
1 |
|
|
|
|
14-11-2020 |
|
224 |
60 |
0.66 |
|
15-11-2020 |
|
288 |
61 |
|
|
16-11-2020 |
|
435 |
66 |
|
|
17-11-2020 |
|
411 |
73 |
|
|
04-12-2020 |
1 |
|
|
|
|
05-12-2020 |
|
305 |
121 |
|
|
06-12-2020 |
|
432 |
125 |
1.08 |
|
07-12-2020 |
|
498 |
127 |
|
|
08-12-2020 |
|
531 |
135 |
|
MTX: (methotrexate) Dose in mg/m2; ALT: Alanine Amino Transferase; GGT: Gamma Glutamyl Transferase; PC: Plasma Concentrations at 36 hours after methotrexate administration in µmol/L