Reccurent Sebaceous Gland Carcinoma of the Eyelid with Metastasis to the Parotid Gland and the Regional Lymph Nodes: Case Report and Review of the Literature

Sebaceous cell carcinoma is a rare cutaneous aggressive tumor arising from the sebaceous glands. . Its almost exclusive site of occurrence is the eyelid but it has also been reported primarily in other sites, such as the parotid region. It is one of the most dangerous tumors, due to masquerading as inflammatory conditions, such as blepharoconjunctivitis, superior limbic keratoconjunctivitis or chalazion. It may also be misdiagnosed as other malignancies, while the incidence of metastasis is high-about 41%. In our article we report a rare case of a reccurent sebaceous gland carcinoma of the eyelid with metastasis to the parotid gland and the regional lymph nodes. In the review of the literature, diagnosis, treatment and the prognosis of this rare entity are described. Citation: Margarita V, Vaia-Aikaterini A, Maria K, et al. (2019) Reccurent Sebaceous Gland Carcinoma of the Eyelid with Metastasis to the Parotid Gland and the Regional Lymph Nodes: Case Report and Review of the Literature. J Head Neck Surg 2(1):13-17 Margarita et al. J Head Neck Surg 2019, 2(1):13-17 Open Access | Page 14 | that had been dissected, were positive for metastasis of the above carcinoma. The patient underwent further radiotherapy and is under regular follow-up in the external unit of our clinic (Figure 4a, Figure 4b). There is no recurrence so far.


Introduction
Sebaceous cell carcinoma is a cutaneous aggressive tumor arising from the sebaceous glands. It is considered as the third most common eyelid malignancy after basal and squamous cell carcinomas. Its almost exclusive site of occurrence is the eyelid but it has also been reported primarily in other sites, such as the parotid region. Among western population it accounts for < 1-5.5%, while in Asians it can be observed at about 31-39% [1][2][3][4][5][6][7].
Sebaceous cells are predominantly present in meibomian glands of the tarsal plate, sebaceous glands of ocular adnexa (gland of Zeis), sebaceous glands embedded in caruncle, brow and associated hair follicles of lid skin. The most common site of occurrence is the upper eyelid.
It has been reported as the great masquerader, due to its resemblance to other benign or malignant lesions. In the differential diagnosis chalazion, blepharitis, conjunctivitis, basal cell carcinoma, squamous cell carcinoma, leukoplakia, ocular pemphigoid and carcinoma in-situ must be concerned [1,5,[8][9][10].
We report a case of a parotid metastasis originating from a carcinoma of the upper eyelid, diagnosed as sebaceous cell carcinoma. Diagnosis and treatment of this entity are described.

Case Presentation
An 80-year-old Caucasian woman presented in our clinic with a firm, painless, slowly enlarging mass at her right parotid area with normal overlying skin. The patient had no regional palpable neck nodes. She also presented with a diffused eyelid, thickening in the upper right eyelid, painful in pulpation.
In her medical history she mentioned type I diabetes under medication. The patient had no history of tobacco or alcohol use. In her surgical history, she mentioned excision of a mass of the right lower eyelid four years ago, diagnosed as a squamous cell carcinoma of the skin of the eyelid, and which had been excised in whole, with histologically free margins of excision and depth invasion 4 mm. The patient had taken

Abstract
Sebaceous cell carcinoma is a rare cutaneous aggressive tumor arising from the sebaceous glands. . Its almost exclusive site of occurrence is the eyelid but it has also been reported primarily in other sites, such as the parotid region. It is one of the most dangerous tumors, due to masquerading as inflammatory conditions, such as blepharoconjunctivitis, superior limbic keratoconjunctivitis or chalazion. It may also be misdiagnosed as other malignancies, while the incidence of metastasis is high-about 41%.
In our article we report a rare case of a reccurent sebaceous gland carcinoma of the eyelid with metastasis to the parotid gland and the regional lymph nodes.
In the review of the literature, diagnosis, treatment and the prognosis of this rare entity are described. that had been dissected, were positive for metastasis of the above carcinoma.
The patient underwent further radiotherapy and is under regular follow-up in the external unit of our clinic (Figure 4a, Figure 4b). There is no recurrence so far.

Discussion
Sebaceous carcinoma, sebaceous gland carcinoma (SGC), sebaceous cell carcinoma and meibomian gland carcinoma are all terms used in the literature to malignant neoplasm of no supplementary treatment for that tumor. Due to that history, the mass of the right parotid was considered to be a metastasis from the SCC of the eyelid.
The CT scan ( Figure 1) and MRI of head and neck ( Figure  2a and Figure 2b) indicated a compact mass in the right parotid gland, with dimensions about 36 × 20 mm. The regional lymph nodes were depicted normal.
Full staging was performed preoperatively, including radiographic control of the chest and ultrasound of the upper abdomen that revealed no distant metastasis.
Ophthalmic examination was also performed. Her visual acuity in the right eye was 1/10 in the central position and 2/10 peripherally, without diplopia, proptosis, and displacement of eye ball or limitation of extra-ocular movements. There was also extended conjunctival filtration. The left eye suffered from an operable senile nuclear cataract.
Under general anesthesia, a supraomohyoid selective neck dissection was performed, followed by a radical parotidectomy with sacrifice of the facial nerve and exenteration of the right eye ball. The periorbital muscles were left intact for potential prosthetic reconstruction and the deficit was closured with regional flaps.
The histopathologic evaluation of the lesions revised the previous diagnosis of a squamous cell carcinoma and stated a diagnosis of a sebaceous gland carcinoma. This infiltrated the upper and the lower eyelid, either in situ (Figure 3a) or invading the underlying stroma, showing well and poorly differentiated areas (Figure 3b) and demonstrated a pagetoid spread to the bulbar conjunctiva (Figure 3c). The excision was undertaken in histologically healthy margins. The lesion in the parotid gland proved to be a metastasis of the sebaceous gland carcinoma, demonstrating necrotic areas (Figure 3d). An intraparotid lymph node, as well as a lymph node of level II in the neck dissection, among the total of 10 lymph nodes a papillary or lobular growth pattern of neoplastic cells with evident sebaceous differentiation, or highly atypical neoplastic cells with prominent nuclear pleomorphism. Areas of necrosis and fibrosis are commonly found. The spread of the tumor in the form of infiltrating lobules, nests and cords is characteristic, perineural invasion is observed in about 20% of tumors, whereas vascular invasion is extremely infrequent [2,4,[12][13][14].
The treatment of SGCs is adequate surgical excision with wide surgical margins and fresh frozen section controls. When the tumor diffuses the eyelid, orbital exenteration is required. Radical or selective neck dissection should be performed, to evaluate lymph node metastasis. Adjunctive radiotherapy or chemotherapy are necessary, depending on the stage of the tumor at the time of presentation, or when the surgical margins are diffused [1,3,6,8,9,11,13,15,16].
In our case, the patient presented with a parotid gland metastasis. Given her history of a surgical excision of a squamous cell carcinoma of the lower eyelid 4 years ago, the parotid gland tumor was thought to be a metastatic SCC. Unfortunately, we had no chance to histologically reexamine the sebaceous origin. Sebaceous carcinoma is traditionally classified into two groups: Tumor arising from the ocular adnexa in the periocular area and those arising in the extraocular sites, which commonly involve the head and neck region, the parotid and submandibular glands, the external auditory canal, the trunk and laryngeal or pharyngeal cavities. It is considered to be the third most common eyelid malignancy -after basal cell and squamous cell carcinoma -representing 1-5.5% of all eyelid tumors. However, it is one of the most dangerous tumors, due to masquerading as inflammatory conditions, such as blepharoconjunctivitis, superior limbic keratoconjunctivitis or chalazion. It may also be misdiagnosed as other malignancies. The result is delayed diagnosis or wrong treatment [1,3,5,[7][8][9][10][11].
In addition to its variable clinical appearance, a variable histologic appearance may also occur. As a result, delayed diagnosis or misdiagnosis following biopsy is not uncommon. Eyelid sebaceous gland carcinoma has a characteristic intraepithelial growth pattern, resulting from a pagetoid spread or a full-thickness replacement of the surface epithelium. The tumor may demonstrate well, moderately or poorly differentiated areas. The histologic examination may reveal Well-differentiated tumors have a better prognostic outcome in compare to the poorly differentiated. Confirmation of pagetoid spread is another bad prognostic factor. Other adverse prognostic features include the involvement of both upper and lower eyelid, tumor size more than 10 mm, orbital extension and infiltration of blood vessels and/or lympatics [1,3,[5][6][7]10].
Metastasis can occur by continuous growth, lympatic spread or hematogenous spread. The most common sites of continuous growth is the orbit, the periaucular area and the parotid gland, as well as the regional lymph nodes of level I and II. More rare is distant metastasis to the lung, pleura, liver, brain, pericardium, lips, ethmoid sinus and skull. The overall mortality rate is 5 -10%, while in cases of metastasis the rate may go up to 25% and up to 41% in cases where the duration of symptoms lasts more than six months [1,3,8,9,[11][12][13][14].
previous tumor, in order to clarify the incidence of misdiagnosis. In the histological examination of the present tumor in the eyelids, the characteristic features of a sebaceous gland carcinoma were observed. Furthermore, the tumor in the parotid gland demonstrated the same features, and was proven to be a metastasis of the above carcinoma, while metastases in two regional lymph nodes were also noticed. In the literature, there are only 3 cases reported with metastasis to the parotid gland, while the tumor most commonly metastasizes to the lymph nodes.
SGCs have a high incidence of recurrence. Recurrence is a major problem and can be at the same site or at a different location. It is difficult to say whether it is a true recurrence or instead a new tumor, due to the multicentric nature of SCG.