Table 3: Performance of screening by different combinations of biomarkers.

 

 

Detection rate (%) for a given false positive rate (FPR)

 

PTD < 34 wks

PTD 34-37 wks

PTD < 37 wks

FPR 10%

FPR 10%

FPR 10%

PAPP-A MoM

78.6

20.0

82.1

AFP MoM

85.7

74

79

β-hCG MoM

14.3

0

2.6

Cx

85.7

80.0

82.1

UtA PI MoM

0

4.0

17.9

Risk factor +

PAPP-A MoM

89.1

81.1

84.2

AFP MoM

92.9

76.0

79.5

Cx

85.7

84.0

82.1

Cx + AFP MoM

78.6

88.0

89.7

Cx + AFP MoM + PAPP-A MoM

92.9

89.0

91.1

FPR - false positive rate