Table 1: Participant information and individual trial results.
|
Participant Information |
Stool PCR Resultsa Quantity of C. diff Toxin Genes (genome equivalents per gram of stool) |
CDI Symptom Severity Results (1 = Mild, 5 = Severe) |
|||||||||||||
|
ID |
Age |
Sex |
First-Time CDI? |
Toxin A |
Toxin B |
Diarrhea |
Bloating |
Abdominal Pain / Cramping |
Nausea |
||||||
|
Pre-Trial |
Post-Trial |
Pre-Trial |
Post-Trial |
Pre-Trial |
Post-Trial |
Pre-Trial |
Post-Trial |
Pre-Trial |
Post-Trial |
Pre-Trial |
Post-Trial |
||||
|
1 |
58 |
F |
Yes |
1.02 x 106 |
<dl |
1.51 x 106 |
<dl |
0 |
0 |
3 |
0 |
0 |
0 |
0 |
0 |
|
2 |
75 |
M |
No |
<dl |
<dl |
2.01 x 103 |
<dl |
5 |
2 |
3 |
3 |
4.5 |
4 |
5 |
0 |
|
3 |
79 |
F |
No |
3.65 x 106 |
<dl |
5.45 x 106 |
<dl |
0 |
0 |
4 |
0 |
0 |
0 |
0 |
0 |
|
4 |
54 |
F |
No |
3.29 x 105 |
9.73 x 102 |
9.67 x 106 |
4.64 x 104 |
0 |
0 |
2 |
2 |
0 |
0 |
0 |
0 |
|
5 |
4 |
M |
Yes |
5.32 x 105 |
<dl |
1.30 x 106 |
<dl |
2 |
0 |
0 |
0 |
1 |
0 |
1 |
0 |
|
6 |
38 |
F |
Yes |
<dl |
<dl |
1.12 x 103 |
<dl |
0 |
0 |
2 |
1 |
0 |
0 |
0 |
0 |
|
7 |
47 |
F |
Yes |
<dl |
<dl |
2.67 x 103 |
<dl |
0 |
NRb |
0 |
NR |
0 |
NR |
0 |
NR |
aPCR Clinical Reference = 1.00 x 103
bNR = No Response
Note: None of the participants reported prior hospitalization for CDI or experienced a fever during the trial. Two participants (participant 1 and 5) reported dehydration at trial onset, but hydration status remained unchanged throughout the study. Additional symptom questions not presented here were either universally negative or inconsistently reported; full details are available in the supplementary data.