Table 1: Probiotic Bacteria of Doctor's Biome Colon Health (registered trademarks of DuPont-Danisco).

Bifidobacterium bifidum

Bb-06

This is a specially selected strains of Bifidobacterium bifidum that could be used with a variety of excipients.

Bifidobacterium breve

Bb-03

This strain is a specially selected strain of Bifidobacterium breve. B. breve (Bb-03) has demonstrated very good adhesion to human epithelial cell lines (HT-29) applied in in vitro studies. Bb-03 is tolerant to low pH conditions and survives the presence of bile at concentrations present in the duodenum.

Bifidobacterium lactis

Bi-07®

This strain is a specially selected strain of Bifidobacterium lactis that could be part of a multiple strain custom blend with a variety of excipients. BI-07 has strong adhesion to intestinal cell lines.

Bifidobacterium longum

Bl-05

This is a specially selected strain of Bifidobacterium longum. In vitro studies have shown that B. longum Bl-05 is tolerant to low pH conditions and survives the presence of bile at the concentrations present in the duodenum. B. longum Bl-05 has demonstrated very good adhesion to human epithelial cell lines applied in in-vitro studies.

Bifidobacterium infantis

Bi-26

This is a specially selected strain of Bifidobacterium longum subsp. infantis that could be part of a multiple strain custom blend with a variety of excipients.

Lactobacillus acidophilus

La-14®

This strain is a specially selected strain of Lb. acidophilus. Well-suited for intestinal survival it has a high tolerance to gastrointestinal conditions (acid, bile, pepsin and pancreatin). LA-14 also has strong adhesion to intestinal cell lines. LA-14 may influence immune regulation as demonstrated by the induction of IL-12 and moderate induction of tumor necrosis factors in vitro.

Lactobacillus brevis

Lbr-35

This is a specially selected strain of Lb. brevis that could be part of a multiple strain custom blend with a variety of excipients.

Lactobacillus bulgaricus

Lb-87

This strain is a specially selected strain of Lb. bulgaricus. L. bulgaricus metabolizes and produces D (-)-lactic acid from four sugars: Lactose, glucose, fructose and mannose. LB-87 has the ability to rapidly convert lactose into lactic acid. LB-87 also has the ability to convert lactose into lactate, aiding in lactose digestion.

Lactobacillus casei

Lc-11®

This strain is a specially selected strain of Lb. casei. LC-11 is well suited for intestinal survival and functionality. It is highly tolerant of acid and bile. LC-11 adheres strongly to intestinal Caco--2 cell lines and it inhibits common pathogens.

Lactobacillus gasseri

Lg-36

This strain is a specially selected strain of Lb. gasseri that could be part of a multiple strain custom blend with a variety of excipients.

Lactobacillus paracasei

Lpc-37®

This strain is a specially selected strain of Lb. paracasei. Lpc-37 displayed in vitro inhibition of selected pathogens including Salmonella typhimurium, Staphylococcus aureus, Escherichia coli and Listeria monocytogenes. A five-strain formulation including L. paracasei (Lpc-37) was found to maintain and more rapidly restore microbiota after antibiotic treatment. LPC-37 is well-suited for intestinal survival, it has a high tolerance to gastrointestinal conditions (acid and bile).

Lactobacillus plantarum

Lp-115®

This strain is a specially selected strain of Lb. plantarum. In vitro studies have shown that L. plantarum (Lp-115) is extremely resistant to low pH conditions and survives the presence of bile at concentrations present in the duodenum. Lp-115 displayed in vitro inhibition of selected pathogens including Salmonella typhimurium, Staphylococcus aureus, Escherichia coli and Listeria monocytogenes. LP-115 is well-suited for intestinal survival; it has a high tolerance to gastrointestinal conditions (acid, bile, pepsin and pancreatin) and has strong adhesion to intestinal cell lines. LP-115 may improve specific immune response, as demonstrated in a human clinical study.

Lactobacillus reuteri

1E1

This is a specially selected strain of Lactobacillus reuteri that could be part of a multiple strain custom blend with a variety of excipients.

Lactobacillus rhamnosus

Lr-32®

This strain is a specially selected strain of Lb. rhamnosus. L. rhamnosus (Lr-32) has shown anti-inflammatory properties, as demonstrated through significant protection against TNBS induced colitis in an animal model. L. rhamnosus (Lr-32) may influence immune regulation, as demonstrated by the increased induction of IL-10 in vitro.

Lactobacillus salivarius

Ls-33®

This is a specially selected strain of Lb. salivarius. LS-33 is well-suited for intestinal survival, it has a high tolerance to gastrointestinal conditions (acid, bile, pepsin and pancreatin). LS-33 has a strong adhesion to intestinal cell lines, and ability to inhibit common pathogens. It also has a beneficial modulation of immune functions, it may influence immune regulation, as demonstrated by increased induction of IL-10 in vitro.