Table 3: Recommendations for use of systemic immunomodulatory agents (Adapted from Sidbury 2014) [43].
Recommendations for use of Systemic Immunomodulatory Agents |
Indicated when a patient’s skin disease has significant negative physical, emotional, or social impact and/or topical regiments or phototherapy are ineffective |
All agents should be adjusted to the minimal effective dose |
Dupilumab, cyclosporine, azathioprine, and methotrexate are systemic agents recommended for the treatment of refractory AD. |
Mycophenolate mofetil and Interferon-gamma may be considered as an alternative, variably effective therapies for refractory AD. |
Systemic steroids should be avoided in the treatment of AD, but they can be used exclusively for acute, severe exacerbations. |