Essential Features:

Must be present

·         Pruritus

·         Eczema (acute, subacute, or chronic) with typical morphology and age-specific patterns^*

·         Chronic or relapsing history

Important Features:

Seen in most cases, add support to the diagnosis

·         Early age of onset

·         Atopy

Personal and/or family history IgE reactivity

·         Xerosis

Associated Features:

Help to suggest the diagnosis, but are too non-specific to be used in defining or detecting AD for research and epidemiologic studies

·         Atypical vascular responses (e.g.,delayed blanch response)

·         Keratosis pilaris/pityriasis alba/hyperlinear palms/ichthyosis

·         Ocular/periorbital changes

·         Other regional findings (e.g., perioral/periauricular lesions)

·         Perifollicular accentuation/lichenification/prurigo lesions

Exclusionary Conditions:

·                Scabies

·                Seborrheic dermatitis

·                Contact dermatitis (irritant or allergic)

·                Ichthyoses

·                Cutaneous T-cell lymphoma

·                Psoriasis

·                Photosensitivity dermatitis

·                Immune deficiency diseases

·                Erythroderma of other causes