Table 3: Comparison of chronic diseases between Covid-19 breakthrough infections and no Covid-19 breakthrough infections in vaccinated people and calculation of relative risks.

Risk factors

chronic diseases*

according to who,

ICD-10 groups

Covid-19 breakthrough infections in vaccinated people

N =30

No  Covid-19 breakthrough infections in vaccinated people

N =1970

Statistical

significance

Relative risk (RR)

-I Infectious

0

20 (0.5)

Fisher exact test = 1. NS

RR = 0 (CI 95%: Infinity,  0) Protection factor effectively

-II Neoplasms

0

153(3)

Fisher exact test = 0.1834. NS

RR = 0 (CI 95%: Infinity,  0) Protection factor effectively

-III Diseases of the blood

2 (3)

87 (2)

Fisher exact test = 0.6561. NS

RR =1.39 (CI 95%: 0, 561299.91). Weak risk

-IV Endocrine

13 (16)

553 (12)

X2 = 1.8161

p = 0.177783. NS

RR =1.5 (CI 95%: 0.76, 2.96). Weak risk

-V Mental

4 (5)

627 (13)

X2 = 4.635

 p = 0.031326 Significant at

p < 0.05

RR = 0.35 (CI 95%: 0.98, 0.12). Protection factor effectively

-VI-VIII Nervous and Senses

10 (13)

367 (8)

X2 = 2.7479

p = 0.097384. NS

RR = 1.73 (CI 95%: 0.82, 3.63). Moderate risk

-IX Circulatory system

10 (13)

867 (18)

X2 = 1.6789

p =  0.195064. NS

RR= 0.65 (CI 95%: 1.35, 0.31). True benefits

-X Respiratory system

3 (4)

393 (8)

X2 = 2.1172

p =  0.145648. NS

RR = 0.44 (CI 95%: 1.59, 0.12).

Protection factor effectively

-XI Digestive system

12 (15)

387 (8)

X2 = 5.335

 p = 0.020901 Significant at

 p < 0.05

RR = 2.03 (CI 95%: 1.05, 3.93). Moderate risk

-XII Diseases of the skin

0

120 (2)

Fisher exact test = 0.2684. NS

RR= 0 (CI 95%: Infinity, 0). Protection factor effectively

-XIII Musculo-skeletal

19 (24)

720 (15)

X2 = 4.9532

p = 0.026042. Significant at p < 0.05 

RR= 1.77 (CI 95%: 1.03, 3.04). Moderate risk

 

-XIV Genitourinary

6 (7)

406 (9)

X2 = 0.0962. p = 0.756492. NS

RR= 0.88 (CI 95%: 8.58, 0.09). Not significant

 

-XVII Congenital malformations

0

20 (0.5)

Fisher exact test = 1. NS

RR= 0 (CI 95%: Infinity, 0). Protection factor effectively

 

-XIX Injury, poisoning and certain other consequences of external causes

0

20 (0.5)

Fisher exact test = 1. NS

RR= 0 (CI 95%: Infinity, 0). Protection factor effectively

 

-XXI Factors influencing health status

0

13 (0.5)

Fisher exact test = 1. NS

RR = 0 (CI 95%: Infinity, 0). Protection factor effectively

 

Total chronic diseases**

79 (100)

4753 (100)

-

-

( ): Denotes percentages; *Patients could have more than one chronic disease. The percentages are over the total of chronic diseases; NS: Not significant at p < 0.05; RR: Relative risk