Table 2: Demographic and laboratory data of children with MIS-C in PICU and non-PICU.
|
|
Non-PICU(N:36) |
PICU (N:32) |
p-value |
Odds ratio (95% confidence interval) |
|
Gender Male (n, %) |
21 (58.3) |
15 (46.9) |
0.345 |
|
|
Age, Months, (median ± SD) |
83.5 ± 59 |
127 ± 50 |
0.002 |
|
|
Obesity (n, %) |
4 (11.4) |
1 (3.1) |
0.196 |
|
|
BMI-SDS (median, IQR kg/m2) |
-0.6 (2.5) |
-0.43 (2) |
0.781 |
|
|
WBC (mean ± SD, /mm3) |
11219 ± 5970 |
11239 ± 6956 |
0.990 |
|
|
Hb (mean ± SD, gr/dL) |
11.1 ± 1.3 |
10.9 ± 1.5 |
0.665 |
|
|
ANC (mean ± SD, /mm3) |
8063 ± 4023 |
9695 ± 6825 |
0.265 |
|
|
ALC (mean ± SD, /mm3) |
2217 ± 1546 |
1005 ± 784 |
< 0.001 |
|
|
Monocyte count (mean ± SD, /mm3) |
741 ± 583 |
409 ± 390 |
0.007 |
|
|
Platelet (mean ± SD, /mm3) |
238194 ± 12897 |
170593 ± 81308 |
0.013 |
|
|
CRP (mean ± SD, mg/L) |
159 ± 81 |
187 ± 67 |
0.137 |
|
|
ESR (mean ± SD, mm/h) |
56.9 ± 31.3 |
63.9 ± 35.9 |
0.399 |
|
|
Ferritin (median, IQR, µg/L) |
293 (8433) |
524 (678) |
0.057 |
|
|
Albumin (mean ± SD, mg/dL) |
3.7 ± 0.6 |
3.1 ± 0.6 |
<0.001 |
|
|
NT-pro BNP (median ± IQR, ng/L) |
1314 (3968) |
3365 (9119) |
0.006 |
|
|
Troponin T (median, IQR, ng/L) |
13 (0.75) |
13 (20) |
0.111 |
|
|
D-Dimer (mean ± SD, µg/L FEU) |
3368 ± 2988 |
3934 ± 3261 |
0.458 |
|
|
Cholesterol (mean ± SD, mg/dL) |
127 ± 36.5 |
124 ± 38 |
0.787 |
|
|
Hypercholesterolemia (n,%) |
0 (0) |
2 (6.3) |
0.231 |
|
|
Triglyceride (mean ± SD, mg/dL) |
176 ± 59 |
186 ± 114 |
0.679 |
|
|
Hypertriglyceridemia (n,%) |
8 (23.5) |
2 (6.3) |
0.084 |
|
|
HDL- C (median, IQR, mg/dL) |
21.5 ± 21.4 |
28 ± 27 |
0.292 |
|
|
Low HDL-C (n, %) |
31 (91.2) |
26 (81.3) |
0.240 |
|
|
LDL- C (mean ± SD, mg/dL) |
73 ± 35 |
61± 33 |
0.176 |
|
|
High LDL-C (n, %) |
3 (9.4) |
2 (6.3) |
1 |
|
|
Insulin (mean ± SD, mU/L) |
20.2 ± 21 |
24.6 ± 16.5 |
0.360 |
|
|
Glucose (mean ± SD, mg/dL) |
90.6 ± 19 |
96.9 ± 29.9 |
0.316 |
|
|
HOMA-IR (mean ± SD) |
5.01 ± 5.8 |
6 ± 4.5 |
0.434 |
|
|
Insulin Resistance (n,%) |
15 (45.5) |
23 (76.7) |
0.011 |
3.943 (1.327-11.712) |
|
TyG index (mean ± SD) |
4.8 ± 0.21 |
4.8 ± 0.35 |
0.961 |
|
|
High Tyg index (n,%) |
32 (94.1) |
26 (81.3) |
0.109 |
|
|
Ejection fraction (mean ± SD) |
62.8 ± 6 |
54.6 ± 9.3 |
< 0.001 |
|
|
Ejection Fraction < 55% (n,%) |
0 (0) |
8 (25) |
0.001 |
2.5 (1.834-3.408) |
|
Coronary artery involvement (n,%) |
6 (16.7) |
8 (25) |
0.396 |
|
|
Unresponsive to IVIG Therapy (n,%) |
11 (30.6) |
27 (84.4) |
< 0.001 |
0.081 (0.025-0.268) |
|
The total length of hospital stay, days, mean ± SD |
8.8 ± 4.4 |
12.9 ± 5.3 |
0.001 |
|
MIS-C: A Multisystem Inflammatory Syndrome in Children; SD: Standard Deviation; BMI: Body Mass Index; WBC: White Blood Count; HB: Hemoglobin; ANC: Absolute Neutrophil Count; ALC: Absolute Lymphocyte Count; ESR: Erythrocyte Sedimentation Rate; NT-Pro BNP: N- Terminal Pro- Brain Natriuretic Peptide; HDL-C: High-Density Lipoprotein Cholesterol; LDL-C: Low-Density Lipoprotein Cholesterol; HOMA-IR: Homeostatic Model Assessment of Insulin Resistance; TYG Index: Triglyceride-Glucose Index; IVIG: Intravenous Immunoglobulin; PICU: Pediatric Intensive Care Unit