Table 3: Presentation of Pseudohypoparathyroid disorders by age in the pediatric population [3, 8, 49-51].
Age | Presentation |
Newborn | • Congenital hypothyroidism |
Infant | • Early onset obesity • Mild delay in acquisition of milestones • Mild or borderline increased TSH |
Toddler < 2 years | • Round face • Rapid weight gain and obesity • Subcutaneous ossifications • Subclinical hypothyroidism |
Children > 2 years | • Moderate mental retardation • Brachydactyly • Afebrile seizures • Short stature, subnormal growth rates due to growth hormone deficiency • Obesity • Subcutaneous ossification |
Adolescence | • Pubertal delay due to gonadotropin resistance • Short stature • Brachydactyly becomes more evident • Dental abnormalities |