Itches, Skin erythemas and Skin rashes dynamic during the study.

Table 2: Itches, Skin erythemas and Skin rashes dynamic during the study.

Characteristics	Group	Category	Day 1		Day 4		Day 7
Characteristics	Group	Category	n	%	n	%	n	%
Itch	Controls	None	15	93.8^a	15	93.8^a	15	93.8^a
		Mild	0	0^a	0	0^a	0	0^a
		Moderate	1	6.3^a	1	6.3^a	1	6.3^a
		Severe	0	0^a	0^a	0^a	0	0^a
	Study group	None	19	90.5^a	20	95.2^a	21	100.0^a
		Mild	1	4.8^a	1	4.8^a	0	0^a
		Moderate	1	4.8^a	0	0^a	0	0^a
		Severe	0	0^a	0	0^a	0	0^a
Skin erythema	Controls	None	15	93.8^a	16	100.0^a	16	100.0^a
		Mild	0	0^a	0	0^a	0	0^a
		Moderate	1	6.3^a	0	0^a	0	0^a
		Severe	0	0^a	0	0^a	0	0^a
	Patients	None	20	95.2^a	20	95.2^a	21	100.0^a
		Mild	0	0^a	0	0^a	0	0^a
		Moderate	1	4.8^a	1	4.8^a	0	0^a
		Severe	0	0^a	0	0^a	0	0^a
Skin rash	Controls	None	15	93.8^a	16	100.0^a	16	100.0^a
		Mild	1	6.3^a	0	0^a	0	0^a
		Moderate	0	0^a	0	0^a	0	0^a
		Severe	0	0^a	0	0^a	0	0^a
	Patients	None	20	95.2^a	20	95.2^a	21	100.0^a
		Mild	0	0^a	1	4.8^a	0	0^a
		Moderate	0	0^a	0	0^a	0	0^a
		Severe	1	4.8^a	0	0^a	0	0^a

^a - The same letters by horizontals mean that there was no statistic significant difference, and the different - that there was statistic significant difference (p < 0.05).