The narcotic activity in term minimum concentration required for narcosis of different compounds and their molecular descriptors along with log Poct value*.

Table 1: The narcotic activity in term minimum concentration required for narcosis of different compounds and their molecular descriptors $(R_{2}, \sum π_{2}^{H}, \sum β_{2}^{0}, V_{x})$ along with log P_oct value*.

Sl.No	Compound	log (1/C_nar)	R₂				V_x	log P_oct
1	Pentane	2.55	0.00	0.00	0.00	0.00	0.81	3.39
2	2-Methylbut-2-ene	2.64	0.16	0.08	0.00	0.07	0.77	2.67
3	Trichloromethane	2.85	0.43	0.49	0.15	0.02	0.62	1.97
4	Tetrachloromethane	3.14	0.46	0.38	0.00	0.00	0.74	2.83
5	Chloroethane	2.35	0.23	0.40	0.00	0.10	0.51	1.43
6	1,2-Dichloroethane	2.63	0.42	0.64	0.10	0.11	0.64	1.48
7	Bromoethane	2.57	0.37	0.40	0.00	0.12	0.57	1.61
8	Iodoethane	2.96	0.64	0.40	0.00	0.15	0.65	2.00
9	Diethylether	1.47	0.04	0.25	0.00	0.45	0.73	0.89
10	Propanone	0.54	0.18	0.70	0.04	0.49	0.55	-0.24
11	Butanone	1.04	0.17	0.70	0.00	0.51	0.69	0.29
12	Pentan-2-one	1.72	0.14	0.68	0.00	0.51	0.83	0.84
13	Pentan-3-one	1.54	0.15	0.66	0.00	0.51	0.83	0.82
14	Camphor	2.88	0.45	0.85	0.00	0.56	1.32	2.53
15	Ethylformate	1.16	0.15	0.66	0.00	0.38	0.61	0.27
16	Methylacetate	1.10	0.14	0.64	0.00	0.45	0.61	0.18
17	Ethylacetate	1.52	0.11	0.62	0.00	0.45	0.75	0.73
18	Propylacetate	1.96	0.09	0.60	0.00	0.45	0.89	1.24
19	Butylacetate	2.30	0.07	0.60	0.00	0.45	1.03	1.82
20	Isobutylacetate	2.24	0.05	0.57	0.00	0.47	1.03	1.60
21	Pentylacetate	2.72	0.07	0.60	0.00	0.45	1.17	2.01
22	Ethylpropanoate	1.96	0.09	0.58	0.00	0.45	0.89	1.21
23	Ethylbutanoate	2.37	0.07	0.58	0.00	0.45	1.03	1.73
24	Ethylpentanoate	2.72	0.05	0.58	0.00	0.45	1.17	2.26
25	Butylpentanoate	3.60	0.03	0.56	0.00	0.45	1.45	3.32
26	Ethylisobutanoate	2.24	0.03	0.55	0.00	0.47	1.03	1.51
27	Triacetin	1.64	0.14	1.30	0.00	0.35	1.60	0.25
28	Acetonitrile	0.44	0.24	0.90	0.07	0.32	0.40	-0.34
29	Nitromethane	1.09	0.31	0.95	0.06	0.31	0.42	-0.33
30	Pentanamide	1.30	0.40	1.30	0.50	0.62	0.93	0.35
31	N-Ethylurethane	1.40	0.24	0.82	0.24	0.61	0.99	1.02
32	Methanol	0.24	0.28	0.44	0.43	0.47	0.31	-0.74
33	Ethanol	0.54	0.25	0.42	0.37	0.48	0.45	-0.30
34	Propan-1-ol	0.96	0.24	0.42	0.37	0.48	0.59	0.25
35	Propan-2-ol	0.89	0.21	0.36	0.33	0.56	0.59	0.05
36	Butan-1-ol	1.42	0.22	0.42	0.37	0.48	0.73	0.84
37	2-Methylprpan-1-ol	1.35	0.22	0.39	0.37	0.48	0.73	0.76
38	2-Methylpropan-2-ol	0.89	0.18	0.30	0.31	0.60	0.73	0.35
39	3-Methylbutan-1-ol	1.64	0.19	0.39	0.37	0.48	0.87	1.28
40	2-Methylbutan-2-ol	1.20	0.19	0.30	0.31	0.60	0.87	0.89
41	Octan-1-ol	3.40	0.20	0.42	0.37	0.48	1.30	3.07
42	Menthol	3.97	0.40	0.48	0.32	0.61	1.47	3.31
43	Ethane-1,2-diol	0.19	0.40	0.90	0.58	0.78	0.51	-1.36
44	Ethanethiol	2.09	0.39	0.35	0.00	0.24	0.55	1.18
45	Carbondisulphide	3.28	0.88	0.26	0.00	0.03	0.49	1.94
46	Triethylphosphate	1.96	0.00	1.00	0.00	1.06	1.39	0.80
47	Benzene	2.68	0.61	0.52	0.00	0.14	0.72	2.13
48	m-Xylene	3.42	0.62	0.52	0.00	0.16	1.00	3.20
49	Naphthalene	4.19	1.34	0.92	0.00	0.20	1.09	3.30
50	Phenanthrene	5.25	2.06	1.29	0.00	0.26	1.45	4.46
51	Methylphenylether	2.82	0.71	0.75	0.00	0.29	0.92	2.11
52	1,3-Dimethoxybenzene	3.35	0.82	1.01	0.00	0.45	1.12	2.21
53	1,4-Dimetoxybenzene	3.05	0.81	1.00	0.00	0.50	1.12	2.03
54	Acetophenone	3.04	0.82	1.01	0.00	0.48	1.01	1.63
55	Aniline	1.96	0.96	0.96	0.26	0.50	0.82	0.90
56	N, N-dimethyl aniline	2.85	0.96	0.84	0.00	0.47	1.10	2.31
57	Diphenylamine	4.43	0.70	0.88	0.60	0.38	1.42	3.50
58	Azobenzene	4.74	0.68	1.20	0.00	0.44	1.48	3.82
59	Acetanilide	2.31	0.87	1.40	0.50	0.67	1.11	1.16
60	p-methoxyacetanilide	2.09	0.97	1.63	0.48	0.86	1.31	1.05
61	p-ethoxyacetanilide	2.55	0.94	1.60	0.48	0.84	1.45	1.58
62	Phenol	2.28	0.81	0.89	0.60	0.30	0.78	1.50
63	o-Cresol	2.92	0.84	0.86	0.52	0.30	0.92	1.98
64	m-Cresol	2.75	0.82	0.88	0.57	0.34	0.92	1.98
65	p-Cresol	2.75	0.82	0.87	0.57	0.31	0.92	1.97
66	2-Isopropylphenol	4.26	0.82	0.79	0.52	0.44	1.34	3.30
67	4-tert-Pentylphenol	4.52	0.81	0.89	0.56	0.41	1.48	3.83
68	2-Methoxyphenol	2.57	0.84	0.91	0.22	0.52	0.97	1.32
69	Catechol	2.12	0.97	1.07	0.85	0.52	0.83	0.88
70	Resorcinol	1.64	0.98	1.00	1.10	0.58	0.83	0.80
71	Hydroquinone	2.12	1.00	1.00	1.16	0.60	0.83	0.59
72	Vanilin	2.48	1.04	1.04	0.32	0.67	1.13	1.21
73	Eugenol	3.91	0.95	0.99	0.22	0.51	1.35	2.99
74	Phenylthiourea	2.18	1.25	1.72	0.49	0.78	1.18	0.73
75	Coumarin	3.24	1.06	1.79	0.00	0.46	1.06	1.32
76	Phthalide	2.37	0.95	1.90	0.00	0.46	0.96	0.80
77	Piperonol	2.78	0.99	1.60	0.00	0.52	1.02	1.05
78	Pyridine	1.60	0.63	0.84	0.00	0.47	0.68	0.65
79	Quinoline	2.72	1.27	0.97	0.00	0.51	1.04	2.03
80	Antipyrine	1.89	1.32	1.50	0.00	1.48	1.55	0.23
81	Caffine	1.92	1.40	1.55	0.00	1.34	1.36	-0.07
82	Morphine	2.76	2.20	2.34	0.86	1.79	2.06	0.76
83	Phenylurea	2.34	1.11	1.40	0.77	0.77	1.07	0.83
84	Acetamide	0.77	0.46	1.30	0.54	0.68	0.51	-1.26
85	Methylurethane	0.57	0.26	0.82	0.24	0.61	0.85	0.34
86	Nicotine	3.51	0.87	1.34	0.00	0.94	1.37	1.17
87	2-Propylpiperidine	3.48	0.36	0.44	0.10	0.69	1.23	2.15
88	Urea	0.60	0.50	1.00	0.50	0.90	0.46	-2.11
89	N-Ethylurethane	1.46	0.24	0.82	0.24	0.61	0.99	1.02
90	N-Propylurethane	2.18	0.23	0.82	0.24	0.61	1.13	1.55
91	N-Isobutylurethane	2.50	0.20	0.79	0.24	0.61	1.27	2.02
92	N-Isopentylurethane	2.93	0.19	0.79	0.24	0.61	1.41	2.64
93	Methanol	0.23	0.28	0.44	0.43	0.47	0.31	-0.74
94	Ethanol	0.72	0.25	0.42	0.37	0.48	0.45	-0.30
95	Propan-1-ol	1.14	0.24	0.42	0.37	0.48	0.59	0.25
96	Butan-1-ol	1.97	0.22	0.42	0.37	0.48	0.73	0.84
97	Pentan-1-ol	2.54	0.22	0.42	0.37	0.48	0.87	1.51
98	Hexan-1-ol	3.24	0.21	0.42	0.37	0.48	0.01	2.03
99	Heptan-1-ol	3.64	0.21	0.42	0.37	0.48	1.15	2.62
100	Octan-1-ol	4.24	0.20	0.42	0.37	0.48	1.30	3.07
101	Nonan-1-ol	4.43	0.19	0.42	0.37	0.48	1.44	3.77
102	Decan-1-ol	1.90	0.19	0.42	0.37	0.48	1.58	4.18
103	Undecan-1-ol	5.09	0.18	0.42	0.37	0.48	1.72	4.72
104	Dodecan-1-ol	5.33	0.18	0.42	0.37	0.48	1.86	5.13
105	Butan-2-ol	1.77	0.22	0.36	0.33	0.56	0.73	0.65
106	Pentan-2-ol	2.32	0.20	0.36	0.33	0.56	0.87	1.25
107	Hexan-2-ol	2.86	0.19	0.36	0.33	0.56	1.01	1.76
108	Heptan-2-ol	3.48	0.19	0.36	0.33	0.56	1.15	2.31
109	Octan-2-ol	4.21	0.16	0.36	0.33	0.56	1.30	2.90
110	Cyclohexanol	2.30	0.46	0.54	0.32	0.57	0.90	1.23
111	Cycloheptanol	2.89	0.51	0.54	0.32	0.58	1.05	1.80
112	Cyclooctanol	3.41	0.58	0.54	0.32	0.58	1.19	2.36
113	Cyclodecanol	4.08	0.62	0.54	0.32	0.58	1.47	3.48
114	Pentan-1,5-diol	1.72	0.39	0.95	0.72	0.92	0.93	-0.25
115	Hexan-1,6-diol	1.60	0.39	0.95	0.75	0.92	1.07	0.25
116	Heptan-1,7-diol	2.48	0.38	0.95	0.75	0.92	1.21	0.78
117	Octan-1,8-diol	3.02	0.38	0.95	0.75	0.92	1.35	1.32
118	Nonan-1,9-diol	3.19	0.37	0.95	0.75	0.92	1.49	1.85
119	Decan-1,10-diol	3.60	0.37	0.95	0.75	0.92	1.64	2.39
120	Dodecan-1,12-diol	4.41	0.36	0.95	0.75	0.92	1.92	3.46
121	Acetal	1.92	0.00	0.67	0.00	0.08	1.07	0.84
122	Benzamide	2.52	0.99	1.50	0.49	0.67	0.97	0.64
123	Benzylalcohol	2.70	0.80	0.87	0.39	0.56	0.92	1.10

*All the values were taken from [35].