Table 12: R-groups (fragments, building blocks, substituents) used in the design
of the diversity library of ART moiety substitution AVSH analogs.
|
Name |
R1 |
R2 |
R3 |
R |
|
|
|
|
|
DihydroART |
|
6A-Dihydro |
Benzyl |
---H |
Phenyl |
OH |
|
6B-Dihydro |
Benzyl |
|||
|
6C-Dihydro |
---(CH2)2-Ph |
|||
|
6D-Dihydro |
Isopropyl |
|||
|
6E-Dihydro |
Benzyl |
---Me |
||
|
6F-Dihydro |
Isopropyl |
---Me |
||
|
|
|
|
|
DihydroArtemether |
|
6A-Arteether |
Benzyl |
---H |
Phenyl |
OCH3 |
|
6B-Arteether |
Benzyl |
|||
|
6C-Arteether |
---(CH2)2-Ph |
|||
|
6D-Arteether |
Isopropyl |
|||
|
6E-Arteether |
Benzyl |
---Me |
||
|
6F-Arteether |
Isopropyl |
---Me |
||
|
|
|
|
|
DihydroArteether |
|
6A-Artémether |
Benzyl |
---H |
Phenyl |
OCH2CH3 |
|
6B-Artémether |
Benzyl |
|||
|
6C-Artémether |
---(CH2)2-Ph |
|||
|
6D-Artémether |
Isopropyl |
|||
|
6E-Artémether |
Benzyl |
---Me |
||
|
6F-Artémether |
Isopropyl |
---Me |
||
|
|
|
|
|
DihydroArtesunate |
|
6A-Artésunate |
Benzyl |
---H |
Phenyl |
OCO (CH2)2COOH |
|
6B-Artésunate |
Benzyl |
|||
|
6C-Artésunate |
---(CH2)2-Ph |
|||
|
6D-Artésunate |
Isopropyl |
|||
|
6E-Artésunate |
Benzyl |
---Me |
||
|
6F-Artésunate |
Isopropyl |
---Me |