Table 11: Statistical indicators of the ten generated pharmacophores hypotheses of FP2 inhibition by AVSHx.
| Hypotheses | RMSDa | R2b | Total costc |
|---|---|---|---|
| Hypo1 | 0.644 | 0.99 | 25.2 |
| Hypo2 | 0.257 | 0.99 | 26.2 |
| Hypo3 | 0.293 | 0.99 | 26.2 |
| Hypo4 | 0.631 | 0.99 | 26.5 |
| Hypo5 | 0.955 | 0.99 | 26.8 |
| Hypo6 | 1.648 | 0.99 | 32.1 |
| Hypo7 | 1.007 | 0.99 | 32.5 |
| Hypo8 | 1.048 | 0.99 | 32.7 |
| Hypo9 | 1.682 | 0.99 | 33.1 |
| Hypo10 | 1.845 | 0.99 | 36.4 |
| Fixed cost | 0.0 | 1.0 | 24.1 |
| Null cost | 12.75 | 0.0 | 494.2 |
aRoot Mean Square Deviation (RMSD); bSquared correlation coefficient; cOverall cost parameter of the PH4 pharmacophore.