Table 2: Results of GO enrichment analysis of common up and down regulated genes.

GO Term

Reference genes in category

Description

DGEs count

Gene names

0051248

20

Negative regulation of protein metabolic process

8

CTSZ, GPX1, GSTP1, IGFBP3, ITM2C, MAGEA2, MAGEA3, MECOM

0010941

30

Regulation of cell death

10

CTSZ, GPX1, GSTP1, IGFBP3, MAGEA3, MALT1, MECOM, MSX1, PAX8, TRIM2

0030162

6

Regulation of proteolysis

4

CTSZ, GPX1, MAGEA3, MALT1

0032269

17

Negative regulation of cellular protein metabolic process

7

CTSZ, GPX1, GSTP1, IGFBP3, MAGEA2, MAGEA3, MECOM

0043281

4

Regulation of cysteine-type endopeptidase activity involved in apoptotic process

7

GPX1, MAGEA3, MALT1

0045861

4

Negative regulation of proteolysis

3

CTSZ, GPX1, MAGEA3

0052548

4

Regulation of endopeptidase activity

3

GPX1, MAGEA3, MALT1

2000116

4

Regulation of cysteine-type endopeptidase activity

3

GPX1, MAGEA3, MALT1

0043067

29

Regulation of programmed cell death

9

GPX1, GSTP1, IGFBP3, MAGEA3, MALT1, MECOM, MSX1, PAX8, TRIM2

0019904

12

Protein domain specific binding

5

CCN1, CXADR, GPX1, SCNN1A, TCEAL9

0004602

2

Glutathione peroxidase activity

2

GPX1, GSTP1

0070062

49

Extracellular exosome

14

ACSL4, AKR1B1, CRISPLD1, CTSZ, FSTL1, GREB1, GSTP1, IGFBP7, ITM2C, LDHB, MSN, PSAT1, RAB34, SCNN1A

0043230

50

Extracellular organelle

14

ACSL4, AKR1B1, CRISPLD1, CTSZ, FSTL1, GREB1, GSTP1, IGFBP7, ITM2C, LDHB, MSN, PSAT1, RAB34, SCNN1A

1903561

50

Extracellular vesicle

14

ACSL4, AKR1B1, CRISPLD1, CTSZ, FSTL1, GREB1, GSTP1, IGFBP7, ITM2C, LDHB, MSN, PSAT1, RAB34, SCNN1A

0044432

28

Endoplasmic reticulum part

9

ACSL4, COL9A2, CTSZ, FADS2, FSTL1, GJA1, IGFBP3, IGFBP7, RCN1