Table 4: Adjusted Odds Ratios (ORs) of BC for acid load scores (PRAL and NEAP), with global estimations and stratified analyses by menopausal status and family history of BC.

SCORE LEVELS

 

           I

             II

               III

              IV

 

 

OR 95% CI

OR 95% CI

OR 95% CI

OR 95% CI

 

PRAL (mEq/d)

     ≤ 12.1

      12.2 - 22.7

        22.8 - 34.9

          > 34.9

Trend (p)

All

1.00        ---

1.01 0.73-1.40

1.76 1.28-2.42

2.46 1.76-3.44

< 0.001

 

 

 

 

 

 

Prem

1.00        ---

0.99 0.43-2.27

2.26 0.97-5.25

3.33 1.41-7.89

0.002

Postm

1.00        ---

1.02 0.72-1.46

1.71 1.21-2.41

2.31 1.61-3.33

< 0.001

 

 

 

 

 

 

FH No

1.00        ---

0.88 0.61-1.25

1.62 1.15-2.27

2.12 1.48-3.04

< 0.001

FH Yes

1.00        ---

2.06 0.93-4.52

2.97 1.22-7.23

6.14 2.30-16.4

< 0.001

 

 

 

 

 

 

NEAP (mEq/d)

    ≤ 68.0

       68.1 - 82.4

    82.5 - 99.2

          > 99.2

 Trend (p)

All

1.00        ---

0.98 0.72-1.35

1.56 1.15-2.13

1.78 1.30-2.42

< 0.001

 

 

 

 

 

 

Prem

1.00        ---

0.76 0.34-1.71

1.39 0.65-2.98

1.49 0.69-3.26

0.14

Postm

1.00        ---

1.00 0.71-1.42

1.63 1.16-2.29

1.82 1.29-2.56

< 0.001

 

 

 

 

 

 

FH No

1.00        ---

0.97 0.69-1.36

1.43 1.03-2.00

1.58 1.13-2.22

0.001

FH Yes

1.00        ---

1.05 0.47-2.32

2.64 1.12-6.19

3.38 1.41-8.11

0.001

The equations included terms for: age (categorical), residence (binary), education (categorical), age at menarche (categorical), menopausal status (binary), age at first live birth (categorical), number of live births (categorical), age at menopause (categorical), family history of BC (binary), BMI (continuous), smoking intensity in pack-years (continuous), alcohol status (categorical) and energy intake (categorical) as independent variables, and cancer (yes/no) was the dependent one.


Likelihood ratio tests for heterogeneity were: non significant for Menopausal status (p = 0.72) and significant for Family history of BC (p = 0.03).

 

Abbreviations: Prem = premenopausal; Postm = postmenopausal; FH = family history of breast cancer in relatives of 1st and 2nd degree together.

 

Bold letters indicate statistically significant values.