Table 2: Univariate and Multivariate Model for the Association with Overall Survival (OS).
Variable |
UVA HR (95% CI) |
p-value
|
MVA HR (95% CI) |
p-value |
|
Treatment Cohort |
Local Therapy |
0.57 (0.51-0.63) |
< 0.001 |
0.69 (0.62-0.77) |
< 0.001 |
Local Therapy + Hormone |
0.33 (0.30-0.38) |
0.51 (0.45-0.58) |
|||
Lumpectomy Alone |
Ref |
Ref |
|||
Age (quartile) |
> 68, < = 90 |
11.64 (9.89-13.70) |
< 0.001 |
6.48 (5.31-7.91) |
< 0.001 |
> 59, < = 68 |
3.28 (2.74-3.93) |
2.49 (2.05-3.01) |
|||
> 51, < = 59 |
1.77 (1.45-2.17) |
1.67 (1.36-2.05) |
|||
> = 23, < = 51 |
Ref |
Ref |
|||
Race |
Black |
1.31 (1.16-1.48) |
< 0.001 |
1.37 (1.21-1.55) |
< 0.001 |
Other/Unknown |
0.51 (0.40-0.67) |
0.67 (0.52-0.88) |
|||
White |
Ref |
Ref |
|||
Charlson-Deyo Score |
2+ |
4.58 (3.85-5.45) |
< 0.001 |
2.82 (2.37-3.36) |
< 0.001 |
1 |
1.93 (1.72-2.16) |
1.42 (1.27-1.59) |
|||
0 |
Ref |
Ref |
|||
Facility Type |
Community Cancer Program/Other |
1.32 (1.13-1.53) |
0.006 |
1.21 (1.04-1.41) |
0.107 |
Comprehensive Community Cancer Program |
1.09 (0.98-1.20) |
1.03 (0.93-1.15) |
|||
Integrated Network Cancer Program |
1.06 (0.92-1.23) |
1.04 (0.90-1.21) |
|||
Academic/Research Program |
Ref |
Ref |
|||
Primary Payor |
Not Insured/Unknown |
2.48 (1.89-3.26) |
< 0.001 |
1.87 (1.42-2.48) |
< 0.001 |
Medicaid/Other Government |
2.35 (1.91-2.91) |
2.03 (1.64-2.52) |
|||
Medicare |
5.42 (4.92-5.97) |
1.74 (1.53-1.98) |
|||
Private |
Ref |
Ref |
|||
Year of Diagnosis |
> = 2004, < = 2008 |
0.93 (0.78-1.11) |
0.204 |
NS |
|
> 2008, < = 2010 |
1.04 (0.87-1.24) |
||||
> 2010, < = 2012 |
0.96 (0.78-1.18) |
||||
> 2012, < = 2013 |
Ref |
||||
Histology |
Comedocarcinoma |
1.04 (0.93-1.16) |
< 0.001 |
NS |
|
Papillary |
1.56 (1.27-1.90) |
||||
Ductal + lobular |
0.81 (0.66-1.00) |
||||
Ductal |
Ref |
||||
ERPR |
ERPR+ |
0.76 (0.69-0.85) |
< 0.001 |
0.95 (0.85-1.05) |
0.348 |
ERPR - |
Ref |
Ref |
|||
HER2 |
Negative |
1.08 (0.78-1.48) |
0.582 |
NS |
|
Unknown |
0.97 (0.75-1.27) |
||||
Positive |
Ref |
||||
Grade |
Moderately Differentiated |
1.0 (0.87-1.17) |
0.765 |
NS |
|
Poorly Differentiated/Undifferentiated |
0.96 (0.83-1.10) |
||||
Cell Type Not Determined |
1.00 (0.85-1.17) |
||||
Well differentiated |
Ref |
||||
Tumor Size Quartile (cm) |
> 0.5, < 1 |
|
0.002 |
1.25 (1.09-1.44) |
0.004 |
> 1, < = 2 |
1.28 (1.12-1.47) |
1.17 (1.02-1.36) |
|||
> 2, < = 99 |
1.19 (1.03-1.37) |
1.27 (1.10-1.46) |
|||
Unknown |
1.26 (1.10-1.45) |
1.11 (0.98-1.26) |
|||
> 0.1, < 0.5 |
Ref |
Ref |
*NS: Not selected by the backward variable elimination, and not significant at p < 0.2.