Table 2: Univariate and Multivariate Model for the Association with Overall Survival (OS).

Variable

UVA HR

(95% CI)

p-value

 

MVA HR

(95% CI)

p-value

Treatment Cohort

Local Therapy

0.57 (0.51-0.63)

< 0.001

0.69 (0.62-0.77)

< 0.001

Local Therapy + Hormone

0.33 (0.30-0.38)

0.51 (0.45-0.58)

Lumpectomy Alone

Ref

Ref

Age (quartile)

> 68, < = 90

11.64 (9.89-13.70)

< 0.001

6.48 (5.31-7.91)

< 0.001

> 59, < = 68

3.28 (2.74-3.93)

2.49 (2.05-3.01)

> 51, < = 59

1.77 (1.45-2.17)

1.67 (1.36-2.05)

> = 23, < = 51

Ref

Ref

Race

Black

1.31 (1.16-1.48)

< 0.001

1.37 (1.21-1.55)

< 0.001

Other/Unknown

0.51 (0.40-0.67)

0.67 (0.52-0.88)

White

Ref

Ref

Charlson-Deyo Score

2+

4.58 (3.85-5.45)

< 0.001

2.82 (2.37-3.36)

< 0.001

1

1.93 (1.72-2.16)

1.42 (1.27-1.59)

0

Ref

Ref

Facility Type

Community Cancer Program/Other

1.32 (1.13-1.53)

0.006

1.21 (1.04-1.41)

0.107

Comprehensive Community Cancer Program

1.09 (0.98-1.20)

1.03 (0.93-1.15)

Integrated Network Cancer Program

1.06 (0.92-1.23)

1.04 (0.90-1.21)

Academic/Research Program

Ref

Ref

Primary Payor

Not Insured/Unknown

2.48 (1.89-3.26)

< 0.001

1.87 (1.42-2.48)

< 0.001

Medicaid/Other Government

2.35 (1.91-2.91)

2.03 (1.64-2.52)

Medicare

5.42 (4.92-5.97)

1.74 (1.53-1.98)

Private

Ref

Ref

Year of Diagnosis

> = 2004, < = 2008

0.93 (0.78-1.11)

0.204

NS

 

> 2008, < = 2010

1.04 (0.87-1.24)

> 2010, < = 2012

0.96 (0.78-1.18)

> 2012, < = 2013

Ref

Histology

Comedocarcinoma

1.04 (0.93-1.16)

< 0.001

NS

 

Papillary

1.56 (1.27-1.90)

Ductal + lobular

0.81 (0.66-1.00)

Ductal

Ref

ERPR

ERPR+

0.76 (0.69-0.85)

< 0.001

0.95 (0.85-1.05)

0.348

ERPR -

Ref

Ref

HER2

Negative

1.08 (0.78-1.48)

0.582

NS

 

Unknown

0.97 (0.75-1.27)

Positive

Ref

Grade

Moderately Differentiated

1.0 (0.87-1.17)

0.765

NS

 

Poorly Differentiated/Undifferentiated

0.96 (0.83-1.10)

Cell Type Not Determined

1.00 (0.85-1.17)

Well differentiated

Ref

Tumor Size Quartile (cm)

> 0.5, < 1

 

0.002

1.25 (1.09-1.44)

0.004

> 1, < = 2

1.28 (1.12-1.47)

1.17 (1.02-1.36)

> 2, < = 99

1.19 (1.03-1.37)

1.27 (1.10-1.46)

Unknown

1.26 (1.10-1.45)

1.11 (0.98-1.26)

> 0.1, < 0.5

Ref

Ref

*NS: Not selected by the backward variable elimination, and not significant at p < 0.2.