Table 2: Suppression/down regulation of physiological anticoagulant pathways in bacterial meningitis.

References

Natural anticoagulant pathways

Perturbation in bacterial meningitis

[59-62]

Heparin-Antithrombin pathway

·        Decreased levels of antithrombin

·        Decreased binding of antithrombin to the endothelium & decreased activity of antithrombin

[59,70,77]

Endothelium-Protein C

·        Downregulation of endothelial thrombomodulin expression

·        Suppress thrombomodulin and endothelial protein C receptor gene transcription