Table 2: Suppression/down regulation of physiological anticoagulant pathways in bacterial meningitis.
References |
Natural anticoagulant pathways |
Perturbation in bacterial meningitis |
[59-62] |
Heparin-Antithrombin pathway |
· Decreased levels of antithrombin · Decreased binding of antithrombin to the endothelium & decreased activity of antithrombin |
[59,70,77] |
Endothelium-Protein C |
· Downregulation of endothelial thrombomodulin expression · Suppress thrombomodulin and endothelial protein C receptor gene transcription |