Normal anticoagulant pathway

Interactions

Physiological function

Heparin-Antithrombin

Heparin binds to Antithrombin 3 forming Heparin Antithrombin 3 Complex

·        Inhibition of coagulation factors 2a, 9a, 10a, 11a, 12a

·        Inhibition of fibrinogen conversion into fibrin

Protein C

Protein C binds to Thrombomodulin forming Protein C-Thrombomodulin complex

·        Inactivation of coagulation factors 5a and 7a

·        Promote fibrinolysis by inhibition of plasminogen activator 1

Tissue Factor Pathway Inhibitor

Tissue factor pathway inhibitor  binds to tissue factor and factor 7 forming Tissue factor pathway inhibitor- factor 7- tissue factor complex

·        Inhibits tissue factor-factor 7 complex

·        Reduced thrombin generation