Table 1: Proteins that were found to be significantly different between control and AVD- deficient male BALB/c mice (p < 0.05) in order from lowest p-value to highest.

Protein No.

Accession

No.

Gene Name

 

Protein Name

Pept-ides

 

% Cov

Mean Cont

Mean AVD

 

FC

P-value

422

Q9WV80

Snx1

Sorting nexin-1

3

5.75

1.0001

1.2605

1.2603

0.001

 

 

1007

 

 

Q99LI8

 

 

Hgs

Hepatocyte growth factor- regulated tyrosine kinase

substrate

 

 

4

 

 

3.23

 

 

1.0047

 

 

0.7119

 

 

-1.4112

 

 

0.002

1374

Q56A07

Scn2b

Sodium channel subunit beta-2

2

5.58

0.8280

1.2618

1.5238

0.002

1063

P63325

Rps10

40S ribosomal protein S10

2

13.94

1.2953

2.3771

1.8351

0.003

673

O54774

Ap3d1

AP-3 complex subunit delta-1

6

3.67

1.2388

0.6064

-2.0427

0.005

984

Q9R0P5

Dstn

Destrin

3

15.15

0.7890

1.7844

2.2615

0.005

1189

Q9Z2D6

Mecp2

Methyl-CpG-binding protein 2

2

3.31

1.0342

0.6078

-1.7015

0.005

 

163

 

Q8BGQ7

 

Aars

Alanine--tRNA ligase,

Cytoplasmic

 

8

 

6.71

 

1.0410

 

0.7817

 

-1.3316

 

0.006

747

Q61595

Ktn1

Kinectin

3

1.58

1.0268

0.5136

-1.9992

0.008

 

1241

 

Q9CYR6

 

Pgm3

Phosphoacetylglucosamine

mutase

 

3

 

4.98

 

0.9864

 

0.7734

 

-1.2754

 

0.008

 

329

 

Q9D051

 

Pdhb

Pyruvate dehydrogenase E1

component subunit beta

 

5

 

10.03

 

0.7227

 

1.4883

 

2.0593

 

0.008

1420

Q3UBX0

Tmem109

Transmembrane protein 109

3

7.41

1.0633

0.6594

-1.6125

0.008

 

1745

 

Q8VDP6

 

Cdipt

CDP-diacylglycerol--inositol 3-

phosphatidyltransferase

 

2

 

4.7

 

0.9876

 

1.6796

 

1.7006

 

0.009

1593

Q9WV54

Asah1

Acid ceramidase

2

3.05

0.8656

1.3823

1.5969

0.010

732

Q60605

Myl6

Myosin light polypeptide 6

4

21.85

0.9320

0.3505

-2.6588

0.010

 

1069

 

Q9D883

 

U2af1

Splicing factor U2AF 35 kDa

subunit

 

2

 

8.79

 

0.7820

 

0.4190

 

-1.8663

 

0.010

 

553

 

Q68EF6

 

Begain

Brain-enriched guanylate

kinase-associated protein

 

3

 

5.50

 

0.9216

 

0.4622

 

-1.9936

 

0.014

 

1104

 

P27671

 

Rasgrf1

Ras-specific guanine

nucleotide-releasing factor 1

 

3

 

2.46

 

0.9780

 

0.6214

 

-1.5738

 

0.015

631

P15105

Glul

Glutamine synthetase

4

8.58

0.8174

1.4467

1.7698

0.016

 

 

667

 

 

Q9CXZ1

 

 

Ndufs4

NADH dehydrogenase [ubiquinone] iron-sulfur

protein 4

 

 

2

 

 

12.00

 

 

1.0614

 

 

0.5591

 

 

-1.8983

 

 

0.016

558

Q8C8N2

Scai

Protein SCAI

3

7.10

0.8066

1.2477

1.5468

0.017

 

1272

 

Q9ES28

 

Arhgef7

Rho guanine nucleotide

exchange factor 7

 

2

 

2.90

 

0.9912

 

0.5186

 

-1.9114

 

0.018

 

287

 

P63024

 

Vamp3

Vesicle-associated membrane

protein 3

 

6

 

38.83

 

0.9981

 

0.5565

 

-1.7936

 

0.020

538

Q9CYZ2

Tpd52l2

Tumor protein D54

3

18.18

0.9264

0.4654

-1.9906

0.021

45

P60469

Ppfia3

Liprin-alpha-3

11

9.88

1.0726

0.8688

-1.2345

0.024

 

1608

 

O54724

 

Ptrf

Polymerase I and transcript

release factor

 

2

 

4.59

 

1.1661

 

0.6941

 

-1.6800

 

0.024

1030

P51855

Gss

Glutathione synthetase

4

7.38

0.8774

0.5838

-1.5029

0.025

263

P12023

App

Amyloid beta A4 protein

6

6.75

1.0800

0.7106

-1.5198

0.026

601

Q8C854

Myef2

Myelin expression factor 2

2

3.89

1.0670

1.7657

1.6548

0.029

 

529

 

O35874

 

Slc1a4

Neutral amino acid transporter

A

 

3

 

7.52

 

0.7254

 

1.0378

 

1.4306

 

0.030

95

P02468

Lamc1

Laminin subunit gamma-1

9

5.41

0.9576

0.6145

-1.5582

0.031

50

Q9QYX7

Pclo

Protein piccolo

21

3.37

1.2671

0.8413

-1.5061

0.032

 

536

 

B1AXV0

 

Frrs1l

DOMON domain-containing

protein FRRS1L

 

3

 

11.6

 

1.0615

 

1.2256

 

1.1545

 

0.033

 

1032

 

P31648

 

Slc6a1

Sodium- and chloride-

dependent GABA transporter 1

 

3

 

3.84

 

1.3463

 

1.7726

 

1.3166

 

0.034

103

P09405

Ncl

Nucleolin

10

9.19

1.1258

0.6735

-1.6715

0.036

858

Q80VP1

Epn1

Epsin-1

2

2.44

0.9593

1.3059

1.3613

0.038

293

Q8CHU3

Epn2

Epsin-2

4

6.72

1.0502

0.6278

-1.6727

0.038

 

2185

 

Q9D8B7

 

Jam3

Junctional adhesion molecule

C

 

2

 

5.16

 

0.9084

 

0.5570

 

-1.6309

 

0.039

703

Q922D8

Mthfd1

C-1-tetrahydrofolate synthase

2

2.67

0.8567

0.6992

-1.2252

0.040

 

199

Q80U49

Kiaa0284

Protein KIAA0284

7

4.70

1.0813

0.6964

-1.5528

0.041

 

543

 

P61089

 

Ube2n

Ubiquitin-conjugating enzyme

E2 N

 

5

 

17.76

 

1.1432

 

0.8175

 

-1.3984

 

0.043

 

 

2209

 

 

Q61290

 

 

Cacna1e

Voltage-dependent R-type calcium channel subunit alpha-

1E

 

 

2

 

 

0.75

 

 

1.3296

 

 

0.8312

 

 

-1.5996

 

 

0.045

1157

Q8K010

Oplah

5-oxoprolinase

2

1.63

0.9406

1.3386

1.4231

0.048

630

P48320

Gad2

Glutamate decarboxylase 2

2

4.44

0.8542

0.4905

-1.7416

0.048

 

1444

 

Q924M7

 

Mpi

Mannose-6-phosphate

Isomerase

 

3

 

4.96

 

1.1433

 

0.5007

 

-2.2834

 

0.049

Abbreviations = Accession No. is the UniProtKB protein code, % Cov = % Coverage (95 CI), FC = Fold Change, Cont = Control AVD = AVD-deficient