Intravenous iron products, recommended dosing, adverse effects and costs [44,63-65,69].

Table 1: Intravenous iron products, recommended dosing, adverse effects and costs [44,63-65,69].

Iron preparation	Dose	Adverse effects	Drug cost per 1000 mg^a
Iron sucrose	200 to 300 mg every 2 days Infusion time: 15 minutes	Headache, muscle cramps, vomiting, diarrhea, nausea	$300-400
Ferric carboxymaltose	750 mg (weight ≥ 50 kg) or 15 mg/kg (weight < 50 kg) every 7 days Infusion time: 15 minutes	Nausea, transient hypertension, flushing, hypophosphatemia, dizziness.	$800-1000
Ferric gluconate	125 mg every 2 days Infusion time: 1 hour	Nausea, vomiting, diarrhea, hypotension, muscle cramps, hypertension, dizziness, dyspnea, chest pain	$150-250
Ferumoxytol	510 mg, 3-8 days apart Infusion time: 15 minutes	Diarrhea, headache, nausea, dizziness, hypotension, constipation, peripheral edema	$1800-2000
Low molecular weight iron dextran^b	100 mg daily (20 mg/kg, maximum 1000 mg) Infusion time: 1 hour	Hypersensitivity reaction, nausea, vomiting, injection site thrombosis or phlebitis	$300-400
Ferric derisomaltose	1000 mg (weight ≥ 50 kg) or 20 mg/kg (weight < 50 kg) Infusion time: 20 minutes	Rash, nausea, hypophosphatemia	Not available^c

^aAssociated costs such as personnel, consumables and capital equipment costs and patient-related costs such as lost wages and transportation not included; ^bTest dose recommended before first therapeutic dose; ^cApproved in the United States February 2020, data not available.