Table 2B: Cases without perioperative complications including patients at risk that either inadvertently or intentionally received triggering agents, example cases 3-5.

Case number Anesthetic agents or modalities Preemptive agents, ERAS and Perioperative Analgesics Other drugs/surgical products received

1

Endotracheal tube and IV agents: midazolam, fentanyl, lidocaine, propofol bolus, succinylcholine, rocuronium, dexamethasone.

Neurophysiologic monitoring with TIVA: propofol and remifentanvl infusions.

Invasive monitoring: Radial arterial line.

Preemptive IV agents: diphenhydramine, Pepcid, hydrocortisione.

Pharmacy compounding PO analgesics: codeine. Acetaminophen IV.

Fentanyl IV.

Antibiotic: cefazolin IV. Instrumentation included cages and allograft: cage filled with local bone graft from osteophyte shavings and demineralized bone matrix. Hemostasis: Tisseel and Arista (specific surgical powder); Tranexamic acid IV. Suture: vicryl, steri-strips.

2

Laryngeal Mask, sevoflurane, and IV agents: midazolam, fentanyl, lidocaine, propofol.

Paracervical block with lidocaine 1% with epinephrine.

Toradol IV.

Odansetron IV.

3

Isobaric spinal bupivicane after local anesthetic skin wheal with lidocaine 1%.

IV agents: midazolam, fentanyl, propofol infusion for sedation.

ERAS PO agents: Celecocib, pregabalin, and acetaminophen.

Intraoperative local Exparel injected into knee compartments (by surgeon protocol).

Oxycodone PO.

Hydromorphone IV.

Antibiotic: cefazolin IV. Cement: Methyl methacrylate.

Tranexamic acid IV.

Odansetron IV.

Suture: monocryl, vicryl, nylon.

4

Endotracheal tube, sevoflurane, and IV agents: midazolam, fentanyl; lidocaine and propofol boluses with infusions; rocuronium, sugammadex. Local anesthetic infiltration of marcaine. 25% with epinephrine at portal sites by surgeon.

ERAS PO agents: celecocib, gabapentin.

Preemptive IV agents: hydrocortisone,

diphenhydramine.

Desmopressin PO.

Acetaminophen IV.

Toradol IV.

Fentanyl IV.

Hydromorphone PO.

Hydromorphone IV.

Antibotics: clindamycin, gentamicin.

Indigo carmine IV.

Odansetron IV.

Suture: vicryl.

Repeat desmopressin PO.

Repeat hydrocortisone IV.

Hydroxyzine PO.

Cetirizine PO.

Amitriptyline.

Buspirone.

5

Endotracheal tube, sevoflurane and IV agents: Midazolam, fentanyl, lidocaine, propofol, succinylcholine, rocuronium, sugammadex.

Local anesthetic infiltration of marcaine.25 % with epinephrine at incision or portal sites by surgeon.

Acetaminophen IV.

Hydromorphone IV.

Antibiotics: piperacillin/tazobactam

Suture: vicryl, monocryl, exofin.

Enoxaparin, subcutaneous prior to surgery; repeated throughout hospitalization.

ERAS: Enhanced Recovery After Surgery; IV: Intravenous; TIVA: Total Intravenous Anesthesia; PO: Oral.