Table 1: Effect of silencing miR-125b on cerebral levels of total Aß, oAß, Total Tau, Phospho-Tau, TNFα and IL-1ß in 5XFAD mice.
Groups | Total Aß | oAß | Total Tau | Phospho- Tau | TNFα | IL-1ß |
Untreated Lts vs. 8-week-old Untreated Tgs |
↑5.2-fold | ↑3.8-fold | ↑6.4-fold | ↑5.8-fold | ↑4.1-fold | ↑4.7-fold |
Untreated Lts vs. 16-week-old Untreated Tgs |
↑7.6-fold | ↑5.5-fold | ↑8.6-fold | ↑6.3-fold | ↑5.7-fold | ↑5.6-fold |
16-week-old Untreated Tgs vs. 16-week-old AM- 125b-treated Tgs |
↓2.1-fold | ↓2.5-fold | ↓2.4-fold | ↓2.5-fold | ↓2.3-fold | ↓2.2-fold |
Abbreviations
ß-amyloid: Aß; oligomeric ß-amyloid: oAß; tumor necrosis factor alpha: TNFα; interleukin-1beta: IL-1ß; Non-transgenic littermate controls: Lts; Transgenic mice: Tgs