Effect of silencing miR-125b on cerebral levels of total Aß, oAß, Total Tau, Phospho-Tau, TNFα and IL-1ß in 5XFAD mice.

Table 1: Effect of silencing miR-125b on cerebral levels of total Aß, oAß, Total Tau, Phospho-Tau, TNFα and IL-1ß in 5XFAD mice.

Groups	Total Aß	oAß	Total Tau	Phospho- Tau	TNFα	IL-1ß
Untreated Lts vs. 8-week-old Untreated Tgs	↑5.2-fold	↑3.8-fold	↑6.4-fold	↑5.8-fold	↑4.1-fold	↑4.7-fold
Untreated Lts vs. 16-week-old Untreated Tgs	↑7.6-fold	↑5.5-fold	↑8.6-fold	↑6.3-fold	↑5.7-fold	↑5.6-fold
16-week-old Untreated Tgs vs. 16-week-old AM- 125b-treated Tgs	↓2.1-fold	↓2.5-fold	↓2.4-fold	↓2.5-fold	↓2.3-fold	↓2.2-fold

Abbreviations
ß-amyloid: Aß; oligomeric ß-amyloid: oAß; tumor necrosis factor alpha: TNFα; interleukin-1beta: IL-1ß; Non-transgenic littermate controls: Lts; Transgenic mice: Tgs