Table 3: Top candidate genes in our data sets that encode targets of existing pharmacological agents (Ingenuity analysis) from [87].

Symbol - description	Brain region (Paradigm) fold-change/P-value		Family	Drug group
ALDH1A1 AF001898	PFC(1)1.34/0.00211 HIP(1)1.22/0.02931	CP(2)1.21/0.028 HIP(3)1.39/0.00103	Enzyme	1
PPP3CA D90035	PFC(3)1.29/0.00282 AMY(3)1.26/0.01712 NAC(1)-1.11/0.0311	AMY(1)1.23/0.02995 CP(3)1.17/0.01792	Phosphatase	2
SCN1A M22253	PFC(1)1.46/0.01392 NAC(1)1.78/0.00133 CP(3)1.17/0.0254	AMY(1)1.69/0.03608 CP(2)-1.25/0.00874 HIP(1)1.44/0.01154	Ion channel	3
NR3C1 M14053	PFC(2)1.47/0.0497 HIP(1)-1.22/0.04664	AMY(1)1.37/0.018	Ligand-dependent nuclear receptor	4
CHRM3 M16407	AMY(1)1.24/0.0131	HIP(3)-1.18/0.03711	G-protein coupled receptor	5
ALDH2 AI172017	AMY(2)1.13/0.03773	NAC(1)1.19/0.03525	Enzyme	1
THRA M31174	AMY(3)1.23/0.04192 HIP(3)1.27/0.01358	CP(1)1.63/0.01932	Ligand-dependent nuclear receptor	6
GABRA1 L08490	AMY(3)1.40/0.02694		Ion channel	7
LPL AI237731	CP(1)-1.58/0.04801 HIP(1)1.32/0.02446	NAC(3)-1.81/0.02148	Enzyme	8
GABRB1 NM_012956	CP(1)-2.65/0.02562	HIP(1)1.57/0.00735	Ion channel	7
GABRD M35162	CP(1)-2.11/0.0258 HIP(2)-1.14/0.01673	CP(1)-1.72/0.03088	Ion channel	7

Abbreviations: ALDH1A1: Aldehyde dehydrogenase family 1, member A1; PPP3CA: Protein phosphatase 3; SCN1A: Catalytic subunit, alpha isoform, sodium channel, voltage-gated, type 1, alpha polypeptide; NR3C1: Nuclear receptor subfamily 3, group C, member 1; CHRM3: Cholinergic receptor, muscarinic 3; ALDH2: Aldehyde dehydrogenase 2; THRA: Thyroid hormone receptor alpha; GABRA1: Gamma-aminobutyric acid receptor, subunit beta 1; LPL: Lipoprotein lipase; GABRB1: Gamma-aminobutyric acid receptor, subunit beta 1; GABRD: Gamma-aminobutyric acid A receptor, delta.

Target-associated pharmacological agents: 1: Disulfiram, 2: Cyclosporine, Fk506, 3: Lamatrogine, lidocaine, phenytoin, prilocaine, procaine, ropivacaine, zonisamide, 4: Beclomethasone dipropionate, betamethasone, dexamethasone/tobramycin, fluticasone, fluticasone/salmeterol, methylprednisolone, mometasone furoate, prednisolone, prednisone, triamcinolone acetonide, 5: Ipratropium, olanzapine, tolterodine, 6: Amiodarone, thyroxine, 7: Clonazepam, diazepam, fioricet, lorazepam, muscimol, olanzapine, sevoflurane, temazepan, zaleplon, zolpidem, 8: Gemfibrozil, nicotinic acid.