Inclusion and exclusion criteria for literature search.

Table 2: Inclusion and exclusion criteria for literature search.

Inclusion criteria	Exclusion criteria
Years searched: 1990 to present. Back volumes were searched if cited in the manuscript.	Review articles (listed for information only), case reports.
English language articles.	Non-English language articles.
Human populations diagnosed as addicted-imaging and blood-chemistry studies.	Therapeutic studies in humans or animals.
Animal studies-BAC toxicokinetics, acute and chronic alcohol drinking, alcohol consumption as primary outcome, behavioral abnormalities.	Studies with insufficient number of animals or animals exposed to non-alcohol drugs (opioid addiction may be included in limited cases).
Animal brain studies-whole animal imaging, stimulatory and inhibitory signaling, genomics, proteomics, metabolomics, epigenetics and alcohol metabolism at different stages (acute euphoric effects, tolerance, and addiction and withdrawal) of alcohol abnormalities.	Secondary analyses of randomized control trials in which the major outcome of interest was not alcohol consumption.
In vitro studies using animal tissue (neural and non-neural) or cell line samples exposed to ethanol for characterization of cell-signaling, gene expression, epigenetics and alcohol metabolism.	In vitro studies using animal tissue (neural and non-neural) or cell line samples exposed to non-alcohol drugs.